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KMID : 0604520150410020159
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Journal of the Society of Cosmetic Scientists of Korea
2015 Volume.41 No. 2 p.159 ~ p.164
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Anti-Inflammatory and Whitening Effect of the Lyophilized Powder of Oriental Plant Extracts Fermented with Streptococcus thermophilus
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Choi Hwa-Jung
Lee Jung-Hee
Yun Mi-Young
Lee Jae-Sug
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Abstract
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To identify new anti-inflammatory and whitening material, this study investigated the whitening and anti-inflammatory effects of the lyophilized powder from 6 oriental plant extracts (OPE; Citrus junos Tanaka, Mori cortex Radicis, Schisandra chinensis Baillon, Coix lachrymajobi var. mayuen, Angelica gigas NAKAI, and Sophora japonica L.) fermented with Streptococcus thermophilus by assessment of cytotoxicity on human dermal fibroblast, inhibitory effect of nitric oxide (NO) prodction, tyrosinase activity and melanin formation. The OPE was fermented with Streptococcus thermophilus at 37 ℃ for 2 days and the lyophilized powder was manufactured by freezing-dryer. OPE didn’t show cytotoxicity at concentration of 500 μg/mL using a cytopathic effect reduction method. OPE also exhibited inhibitory effect on nitric oxide (NO) prodction by Griess reagent system. Furthermore, OPE showed inhibitory effect on tyrosinase activity with dose dependent manner, and exhibited significant inhibition of melanin formation by measurement of melanin from culture media (p < 0.05). From these results, 6 OPE extracts showed anti-inflammatory and whitening effect and may be used as an active ingredient for cosmetics.
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KEYWORD
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anti-inflammatory, whitening, fermented powder, Streptococcus thermophilus, cosmetics
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